The end of WeightWatchers? How the dieting club lost out to slimming drugs

As the global enterprise grapples with reported debts of $1.4bn, its calorie-counting formula may have had its day

Hay fever making your life a misery? Try these 20 tips from doctors and allergy experts

Do nasal sprays work? Which are the best antihistamines? Can honey help? What about a shower? We’ve got all the answers

Ozempic is hailed as a miracle drug. But how does it affect people with eating disorders?

Doctors worry about GLP-1s being used by people with restrictive eating disorders – but research also shows they could help others struggling with binge eating

‘It’s back to drug rationing’: the end of HIV was in sight. Then came the cuts

The abrupt halt to US funding threatens to undo decades of advances, dramatically increasing infections and deaths, but some see an opportunity for Africa to lead the response

‘It’s not ethical and it’s not medical’: how UK rehab clinics are cashing in on NAD+

They are beloved by A-listers and surging in popularity. But claims that NAD+ infusions are a fix for addiction are unproven, risky – and possibly illegal, an Observer investigation reveals

Psychedelic Outlaws by Joanna Kempner review – a compelling case for the use of magic mushrooms in pain relief

The US sociologist’s study of psychoactive fungi to treat little-known medical conditions such as cluster headaches is well researched and wide ranging

I thought I was fine with being bald. But the chance of a cure has stirred up all sorts of feelings

It’s almost 30 years since I lost my hair to alopecia. What if Pfizer’s drug Litfulo could bring it back? asks Guardian columnist Emma Beddington

UK universities urged to end drugs zero tolerance and focus on harm reduction

Report proposing new approach welcomed by mother of Jeni Larmour, who died after taking alcohol and ketamine

Pills or patches, sprays or gels … everything you need to know about HRT

Is hormone replacement therapy right for you and, if it is, what type should you take? All your key questions answered

‘It feels like we’ve been lobotomised’: the possible sexual consequences of SSRIs

Long-term sexual dysfunction is a side-effect for some patients who take these widely prescribed antidepressants, and can leave sufferers devastated

Doctors fighting US opioid epidemic say insurance barrier impedes treatment

Prior authorization requires permission to be sought before prescribing critical drugs, which could cost lives, doctors say

‘Long-lost best friends’: the longevity movement finds psychedelics

The mental-health benefits of psychedelics are a draw for a growing community of people committed to reversing ageing

‘They thought I had cancer’: painkiller banned in UK linked to Britons’ deaths in Spain

Patients’ group says reactions to metamizole can cause sepsis and organ failure – and British and Irish people are at higher risk

My topical steroid withdrawal: ‘Water felt like acid, my body was ablaze and I shed skin like a snake’

I was prescribed steroid cream for my eczema – but when I stopped using it I ended up in A&E. Much more research is needed into this debilitating condition

What is Primodos and why were 100 UK families seeking compensation?

Concerns about birth defects first raised in 1960s but evidence for causal link to pregnancy test remains contentious